Friday, January 04, 2013

Immune system 'booster' may hit cancer

Vast numbers of cells that can attack cancer and HIV have been grown in the lab, and could potentially be used to fight disease.

The cells naturally occur in small numbers, but it is hoped injecting huge quantities back into a patient could turbo-charge the immune system.

The Japanese research is published in the journal Cell Stem Cell.

The researchers concentrated on a type of white blood cell known as a cytotoxic T-cell, which can recognise telltale markings of infection or cancer on the surfaces of cells. If a marking is recognised, it launches an attack.

Teams at the University of Tokyo and the Riken Research Centre for Allergy and Immunology used advances in stem cell technology to make more T-cells.

Dr Hiroshi Kawamoto, who worked on the cancer immune cells at Riken, said: "The next step will be to test whether these T-cells can selectively kill tumour cells, but not other cells in the body.

"If they do, these cells might be directly injected into patients for therapy. This could be realized in the not-so-distant future."

Dr Hiromitsu Nakauchi from the University of Tokyo said it was "unclear" whether this technique would help in treating HIV and that other infections and cancer may be a better place to start.

Prof Alan Clarke, the director of the European Cancer Stem Cell Research Institute at Cardiff University, said: "This is a potentially very exciting development which extends our capacity to develop novel cell therapies."

Prof Sir John Burn, from the Institute of Genetic Medicine at Newcastle University, said: "This is a very appealing concept and the research team are to be congratulated on demonstrating the feasibility of expanding these killer cells.

Source: http://www.bbc.co.uk/news/health-20898931

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